Cultural remnants were left in Sedona Vacation by ancient peoples referred as the Desert Culture, the Anasazi and Hohokam groups. Researchers believe that the Hopi tribes descend from this Sedona Vacation area culture.

Indigenous to Sedona Vacation , the Sinagua, an agrarian society that dry farmed and traded in the Sedona Vacation area during 1100-1400 AD. Commerce in Sedona Vacation was not limited to nearby tribes, but as a hub, trading with Pacific, and South America groups. Sedona Vacation 's area rich minerals, salt and copper were exported items. Peace among tribes prevailed during religious ceremonies that took place in the Sedona Vacation region.

Traces of these ancient civilizations of Sedona Vacation can be found in the great pueblos. The Palatki ruin, constructed by the Sinagua, located between Sedona Vacation and Clarkdale, depicts drawings of snakes and Kokopelli. 50 people or more may have resided in these pueblos. Honanki, another Sinaguan ruin near Sedona Vacation , held around 60 rooms.

Southeast of Sedona Vacation is Montezuma's Castle and Montezuma's Well. Cliff dwellings were also built in the Sedona Vacation region by the Sinagua. The Sedona Vacation area was originally occupied by the Hohokam.

Volcanic disturbances in Sedona Vacation drew the Hohokam to more fertile lands, the Sinagua settled in the Sedona Vacation area, building above ground dwellings. The Sinagua used the irrigation techniques of the Hohokam to tame Sedona Vacation . The Sinagua vanished from Sedona Vacation for reasons unknown.